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69517 Gorxheimertal
+49 (0)6201-878380
What is authentic OPC? Dr. Alexander Michalzik and Dr. rer. nat. Klaus Denzel in conversation
Dr rer. Nat. Klaus Denzel explains the different measuring methods for the content of OPC (oligomeric proanthocyanidins) in food supplements. Polyphenol content is not the same as the OPC content. Also, monomeric or polymeric proanthocyanidins should not be included in OPCs.
Claims from various OPC suppliers such as 440 mg OPC complex suggest that 440 mg OPC is obtainable, but this may represent the entire content of the capsule. In general only a small amount of OPC is contained. Thus the bioavailability of the product should be checked here. Labels such as OPC grape seed extract (oligomeric procyanidins) 300 mg, OPC (95 %) or 200 mg OPC Complex are misleading because usually only a small amount of OPC is actually contained. Often you hear about grape seed extract with 95 % OPC, which likewise does not mean OPC. What signifies an OPC complex? Is it a pure substance or is it a complex? These terms can be misleading.
Almost all suppliers of OPC are located abroad, even though they have a German website. Unfortunately, these providers are rarely or not at all monitored by German authorities because they are unreachable.
You should always insist upon seeing an analysis certificate and also pay attention to the analysis method! OPC 160 Certificate of Analysis (click here to view OPC-analysis)
German companies like Biotikon® are certified.
Suitable for vegetarians & vegans!
The OPC content can be measured by various methods. In our years of experience, we have observed that the safest method is the HPLC-method. In particular we use the RP-HPLC method (PV.03.P194_02) Test specification for OPC analysis (click here to view), wwhich is the most commonly used method of analysis of quality botanicals.
Dr. Michalzik’s OPC is produced under the supervision of medical professionals in Germany. Only materials of the highest quality are used.
Dr. Michalzik’s OPC contains no fillers fillers (resulting in slightly higher production costs) and only natural substances are used, resulting in an exceptionally high concentration of OPC (oligomeric procyanidins). Polyphenols (270 mg of total polyphenols per capsule) are not just OPC! In addition to the OPC other important polyphenols (antioxidant active substances) are included, such as monomeric procyanidins.
According to our company’s philosophy, we leave our OPC in its natural plant compound. Since OPC is fat and water soluble, it is perfectly absorbed by the body (high bioavailability).


Made in Germany.
OPC by Dr. Michalzik is subject to strict examinations of German supervisory authorities. It is manufactured by use of gentle production technologies without heat or additives in the capsule filling and without the use of processing agents which are not required to be mentioned on the packaging.
Biotikon does not use silicon dioxide or silicic acid (SiO2, known as E551) as a flow aid. The foundation for product testing "Stiftung Warentest" states that those may contain nanoparticles. Silicic acid or silicon dioxide in dietary supplements has been discouraged. Bio Suisse has terminated approval of silica or silicon dioxide. Silica from horsetail is not to be confused with this industrially produced silica.
A large number of nutritional supplement providers use aluminum as a sealant for cans. During the sealing process an aluminum foil is strongly heated by a high frequency electromagnetic field. We deliberately do not use this method!
The release agent and lubricant talcum which is used for manufacturing of tablets or capsules can contain asbestos fibers. Biotikon completely dispenses with the use of release agents and lubricants in their capsule production.
From the date of sale all of our products have a long lasting shelf life. This is possible because we process in house.
Biotikon products are manufactured in accordance with legal requirements and in compliance with the HACCP concept











OPC is also contained in our following products:

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Brain & Mental Performance | |
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Eye Formula | |
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Heart Forte I | |
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Blood Pressure Regulator | |
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Joint Formula II | |
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Arterial & Blood Vessel Support | |
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Sport - cell protect | |
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Mitochondrium forte / forte PRO |
1 capsule:
*OPC measured directly in the grape seed extract. (According to RP-HPLC Methode, test specification PV.03.P194_02). OPC are proanthocyanidins. Monomeric proanthocyanidins are not added into the OPCs. Test specifications are available at www.opc-grapeseedextract.de
** Corresponds to 62 % of the National Reference Value (NRV) for a daily intake in accordance with the Food Information Regulation (LMIV).
For questions, please call directly Dr. Alexander Michalzik and Team +49 (0)6201-878380.

Furthermore, several exemplary analyses of grape seed extract used for our OPC products are available for you to view. We will gladly send them to you by mail. The analysis values, measured with the RP-HPLC method, are the basis for specifying our OPC content. The Vanillin method, Butanol method (Procyanidin-Assay) and Porter-Bate-Smith method result in different values Werte. . RP-HPLC_OPC Analysis Certificate (click here)
The following certificates have not been applied to the current OPC batch. They serve as information about OPC analysis.
OPC_DMAC (click here to view PAC-Analysis by DMAC Method)
OPC_Porter_Bate-Smith (click here to view OPC-Analysis by Porter_Bate-Smith)
Certificate of Analysis by Vanillin method, Procyanidin-Assay (Butanol method) and the Pharmacopoeia method (EP6.0 1220) (click here)
- Polyphenols (see diagram) 95%
- OPC-content content in grape seed extract, 160 mg (nach RP-HPLC PV.03.P194_2). OPC sind are proanthocyanidins without monomeric proanthocyanidins
- Total polyphenols 285 mg
- Pure Vitamin C 50 mg**
Ingredients: Extract of Vitis vinifera, capsule material from pure vegetable cellulose: hydroxy-propyl-methyl-cellulose, vitamin C (ascorbic acid)
Purest Quality from Biotikon®
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Pure substances without additives or fillers in the capsule filling |
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Gluten-free, lactose-free and gelatine-free |
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Information about residue control: please contact us |
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Packaging made of HDPE, no plasticisers |
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Without animal testing |
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We deliver fresh products |
1-2 capsules after meals.
Package Contents: 72 OPC capsules, each capsule contains 300 mg of grape seed extract.
Storage: Keep cool & dry, protect from light exposure.
Important Note: The recommended daily dose should not be exceeded. Nutritional supplements are not intended to be a substitute for a varied and balanced diet or a healthy lifestyle. Children, pregnant women, and nursing mothers should consult with a doctor before using this product. Keep out of reach of children.When buying OPC, please take note of the following:
- Documented OPC content with RP-HPLC analysis certificate
- Product should be processed in Germany / German suppliers: Verifiability and security ensured by controllability
- No fillers and additives
- OPC originates from grape seeds. Much knowledge about the product is received from red wine.
Polyphenols of plants are known as phytochemicals.
When OPCs are separated in the body, they no longer form the original blocks (catechins) but substances with a new identity possessing a larger spectrum. Therefore they are called pro cyanidins since they do not disintegrate into catechins but cyanidins. Green tea, for example, contains mainly monomeric (single) catechins, which are not comparable to OPC. A peeled banana turns brown, iron will rust. The reason is the oxidation of these substances by radical oxygen molecules (free radicals).
OPC-products from Biotikon® compared | ||||
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29,90 € |
300 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik, M.D. with at least 160 mg of pure OPC* |
72 Capsules |
|
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OPCPlus |
32,90 € |
300 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik and Camu Camu extract with at least 160 mg of pure OPC* |
72 Capsules |
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OPC Premium |
39,90 € |
450 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik, M.D. with at least 240 mg of pure OPC* |
72 Capsules |
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OPC Premium Plus |
42,90 € |
450 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik, M.D. with Camu Camu extract and at least 240 mg of pure OPC* |
72 Capsules |
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OPC Premium Piperine PRO |
47,90 € |
450 mg of OPC premium grape seed extract per capsule by Dr. Michalzik, containing Piperine and phosphatidylcholine with at least 240 mg of pure OPC* |
72 Capsules |
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OPC from Organic Grapes |
59,90 € |
- currently not available |
60 Capsules |
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OPC GOLD from Organic Grapes |
99,90 € |
- currently not available |
60 Capsules |
„In combination to
OPC
I recommend:”
Dr. med.
Alexander
Michalzik
OPC
is often purchased together with:
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no additives*
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