300 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik, M.D. with at least 160 mg of pure OPC*

Campaign: Buy 3 containers,
get 4th one free of charge
Delivery time 3 - 5 days
Valid for deliveries to the UK, delivery times for other countries, please see: Shipping & Payment

Pharmazentralnummer: 16025551
Die Pharmazentralnummer (PZN) dient der Identifikation deutscher Arzneimittel und Apothekenwaren. Bei der Abrechnung für Privat-Versichterte mit der Krankenkasse ist sie hilfreich. Sie finden die PZN daher auch auf unseren Rechnungen.
Native-OPC – highly effective natural antioxidant by Dr. med. Alexander Michalzik

What is authentic OPC? Dr. Alexander Michalzik and Dr. rer. nat. Klaus Denzel in conversation

Dr rer. Nat. Klaus Denzel explains the different measuring methods for the content of OPC (oligomeric proanthocyanidins) in food supplements. Polyphenol content is not the same as the OPC content. Also, monomeric or polymeric proanthocyanidins should not be included in OPCs.

Currently praised in leading journals. Biotikon® is based in Germany and thus subject to strict regulations.

Claims from various OPC suppliers such as 440 mg OPC complex suggest that 440 mg OPC is obtainable, but this may represent the entire content of the capsule. In general only a small amount of OPC is contained. Thus the bioavailability of the product should be checked here. Labels such as OPC grape seed extract (oligomeric procyanidins) 300 mg, OPC (95 %) or 200 mg OPC Complex are misleading because usually only a small amount of OPC is actually contained. Often you hear about grape seed extract with 95 % OPC, which likewise does not mean OPC. What signifies an OPC complex? Is it a pure substance or is it a complex? These terms can be misleading.

Almost all suppliers of OPC are located abroad, even though they have a German website. Unfortunately, these providers are rarely or not at all monitored by German authorities because they are unreachable.

You should always insist upon seeing an analysis certificate and also pay attention to the analysis method! OPC 160 Certificate of Analysis (click here to view OPC-analysis)

German companies like Biotikon® are certified.

Suitable for vegetarians & vegans!

The OPC content can be measured by various methods. In our years of experience, we have observed that the safest method is the HPLC-method. In particular we use the RP-HPLC method (PV.03.P194_02) Test specification for OPC analysis (click here to view), wwhich is the most commonly used method of analysis of quality botanicals.

Dr. Michalzik’s OPC is produced under the supervision of medical professionals in Germany. Only materials of the highest quality are used.

Dr. Michalzik’s OPC contains no fillers fillers (resulting in slightly higher production costs) and only natural substances are used, resulting in an exceptionally high concentration of OPC (oligomeric procyanidins). Polyphenols (270 mg of total polyphenols per capsule) are not just OPC! In addition to the OPC other important polyphenols (antioxidant active substances) are included, such as monomeric procyanidins.

According to our company’s philosophy, we leave our OPC in its natural plant compound. Since OPC is fat and water soluble, it is perfectly absorbed by the body (high bioavailability).
Nature & Purity

 Made in Germany.

OPC by Dr. Michalzik is subject to strict examinations of German supervisory authorities. It is manufactured by use of gentle production technologies without heat or additives in the capsule filling and without the use of processing agents which are not required to be mentioned on the packaging.
No industrially produced silicic acid (silicon dioxide) flow aid.
Biotikon does not use silicon dioxide or silicic acid (SiO2, known as E551) as a flow aid. The foundation for product testing "Stiftung Warentest" states that those may contain nanoparticles. Silicic acid or silicon dioxide in dietary supplements has been discouraged. Bio Suisse has terminated approval of silica or silicon dioxide. Silica from horsetail is not to be confused with this industrially produced silica.
No Aluminum Contained
A large number of nutritional supplement providers use aluminum as a sealant for cans. During the sealing process an aluminum foil is strongly heated by a high frequency electromagnetic field. We deliberately do not use this method!
Without talcum!
The release agent and lubricant talcum which is used for manufacturing of tablets or capsules can contain asbestos fibers. Biotikon completely dispenses with the use of release agents and lubricants in their capsule production.
Fresh Products!
From the date of sale all of our products have a long lasting shelf life. This is possible because we process in house.
Food Safety HACCP
Biotikon products are manufactured in accordance with legal requirements and in compliance with the HACCP concept in order to ensure food safety.
Please note: With each purchase, you are also automatically supporting chosen social projects. Further information can be found in our blog under Social Engagement .
Free of sugar
Free of lactose
Free of Gluten
Free of gelatin
Not irradiated
Free of magenseium stearate

OPC is also contained in our following products:

OPC Wirkung
Gehirn und geistige Leistung Brain & Mental Performance
Augen Rezeptur Eye Formula
Herzforte 1 I Heart Forte I
Blutdruck Regulat Blood Pressure Regulator
Gelenk-Rezeptur II Joint Formula II
Arterien Blutgefäß Support Arterial & Blood Vessel Support
Sport Concept cell protect Sport - cell protect
Mitochondrium forte/Pro Mitochondrium forte / forte PRO

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Ingredients per Daily Recommendation*
1 capsule:
extract of Vitis vinifera
300 mg
   total polyphenols
270 mg
160 mg
pure vitamin C**
50 mg

*OPC measured directly in the grape seed extract. (According to RP-HPLC Methode, test specification PV.03.P194_02). OPC are proanthocyanidins. Monomeric proanthocyanidins are not added into the OPCs. Test specifications are available at www.opc-grapeseedextract.de

** Corresponds to 62 % of the National Reference Value (NRV) for a daily intake in accordance with the Food Information Regulation (LMIV).

For questions, please call directly Dr. Alexander Michalzik and Team +49 (0)6201-878380.

The following diagram illustrates the different components of grape seed extract.

OPC-Concentration Process

OPC-Concentration Process

Furthermore, several exemplary analyses of grape seed extract used for our OPC products are available for you to view. We will gladly send them to you by mail. The analysis values, measured with the RP-HPLC method, are the basis for specifying our OPC content. The Vanillin method, Butanol method (Procyanidin-Assay) and Porter-Bate-Smith method result in different values Werte. . RP-HPLC_OPC Analysis Certificate (click here)

The following certificates have not been applied to the current OPC batch. They serve as information about OPC analysis.
OPC_DMAC (click here to view PAC-Analysis by DMAC Method)

OPC_Porter_Bate-Smith (click here to view OPC-Analysis by Porter_Bate-Smith)

Certificate of Analysis by Vanillin method, Procyanidin-Assay (Butanol method) and the Pharmacopoeia method (EP6.0 1220) (click here)
Active Substances:
  • Polyphenols (see diagram) 95%
  • OPC-content content in grape seed extract, 160 mg (nach RP-HPLC PV.03.P194_2). OPC sind are proanthocyanidins without monomeric proanthocyanidins
  • Total polyphenols 285 mg
  • Pure Vitamin C 50 mg**

Ingredients: Extract of Vitis vinifera, capsule material from pure vegetable cellulose: hydroxy-propyl-methyl-cellulose, vitamin C (ascorbic acid)

Purest Quality from Biotikon®

Pure substances without additives or fillers in the capsule filling
Gluten-free, lactose-free and gelatine-free
Information about residue control: please contact us
Packaging made of HDPE, no plasticisers
Without animal testing
We deliver fresh products
Daily Recommendation:
1-2 capsules after meals.

Package Contents: 72 OPC capsules, each capsule contains 300 mg of grape seed extract.

Storage: Keep cool & dry, protect from light exposure.

Important Note: The recommended daily dose should not be exceeded. Nutritional supplements are not intended to be a substitute for a varied and balanced diet or a healthy lifestyle. Children, pregnant women, and nursing mothers should consult with a doctor before using this product. Keep out of reach of children.
Additional Information:
When buying OPC, please take note of the following:
  • Documented OPC content with RP-HPLC analysis certificate
  • Product should be processed in Germany / German suppliers: Verifiability and security ensured by controllability
  • No fillers and additives
  • OPC originates from grape seeds. Much knowledge about the product is received from red wine.

Polyphenols of plants are known as phytochemicals.

When OPCs are separated in the body, they no longer form the original blocks (catechins) but substances with a new identity possessing a larger spectrum. Therefore they are called pro cyanidins since they do not disintegrate into catechins but cyanidins. Green tea, for example, contains mainly monomeric (single) catechins, which are not comparable to OPC. A peeled banana turns brown, iron will rust. The reason is the oxidation of these substances by radical oxygen molecules (free radicals).
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Your Biotikon® Advantages:

  • Made in Germany
  • Premium-quality extract
  • Capsule contains
    no additives*
  • free shipping on orders over 70 Euro
  • with also on packing stations,
  • GB 3 - 5 days
  • DE 1 - 3 days
  • AT, CH, EU 3 - 5 days
Order by phone
+49 (0)6201-878380
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and Sat.:
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