300 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik and Camu Camu extract with at least 160 mg of pure OPC*

Delivery time 3 - 5 days
Valid for deliveries to the UK, delivery times for other countries, please see: Shipping & Payment

Pharmazentralnummer: 16025568
Die Pharmazentralnummer (PZN) dient der Identifikation deutscher Arzneimittel und Apothekenwaren. Bei der Abrechnung für Privat-Versichterte mit der Krankenkasse ist sie hilfreich. Sie finden die PZN daher auch auf unseren Rechnungen.
Native OPC with OPC, other polyphenols and camu camu extract. Please note that we supply a Certificate of Analysis! The company headquarters of Biotikon® are in Germany and therefore are subject to strict monitoring. Almost all suppliers of OPC are located abroad, even though they have a German website.

What is authentic OPC? Dr. Alexander Michalzik and Dr. rer. nat. Klaus Denzel in conversation

Dr rer. Nat. Klaus Denzel explains the different measuring methods for the content of OPC (oligomeric proanthocyanidins) in food supplements. Polyphenol content is not the same as the OPC content. Also, monomeric or polymeric proanthocyanidins should not be included in OPCs.

Labels from various OPC or grape seed extract suppliers claim 95% OPC, suggesting that this amount of OPC is obtainable. In general this percentage does not refer to pure OPC, but to OPC grape seed powder, which may only contain small percentages of OPC. Pure OPC is proanthocyanidins without monomeric proanthocyanidins. OPC is defined differently by various manufacturers and can also be measured with alternate analysis procedures. You should always insist upon seeing an analysis certificate and also pay attention to the analysis method! OPC Plus Certificate of Analysis (click here to view OPC-analysis) German companies like Biotikon® are certifiable. A reliable analysis for the measurement of the OPC content is the RP-HPLC method. In particular we use the RP-HPLC method which is the most commonly used analysis method for high-quality plant materials. Other methods may show different values. A statement of OPC 95% should be critically scrutinized.

OPCplus by Dr. Alexander Michalzik additionally contains high-quality camu camu extract (Camu Camu is the richest vitamin C plant known in science).

Suitable for vegetarians & vegans!

OPC by Dr. Michalzik contains an exceptionally high concentration of OPC (oligomeric procyanidins). Only materials of the highest quality are used. Dr. Michalzik’s OPC contains no fillers (resulting in significantly higher production costs) using only natural substances.

Polyphenols are not just OPC! In addition to 160 mg of OPC (according to RP-HPLC test specifications PV.03.P194 02) other important polyphenols (antioxidant active substances) are included. Test specification is available under www.opc-grapeseedextract.de. According to our company’s philosophy, we leave our OPC in its natural plant compound.

Our product is manufactured in Germany by Biotikon® under supervision of Dr. Michalzik®.

Below you will find several exemplary analysis of grape seed extract used for our OPC products.

In part, these are analyses of recent batches. The analysis value measured with the RP-HPLC method which is always up to date, is the basis for specifying our OPC content. We will gladly send the RP-HPLC analysis to you by mail.

For older batches we used the Vanillin method, Butanol method (Procyanidin-Assay) and Porter Bate-Smith method to compare the OPC methods of measurement.

Suitable for vegetarians & vegans!

RP-HPLC_OPC_Analysezertifkat (click here)

OPC_DMAC (click here to view PAC analysis by DMAC method)

OPC_DMAC (click here to view PAC analysis by DMAC method)

Certificate of Analysis by Vanillin method, Procyanidin-Assay (Butanol method) and the Pharmacopoeia method (EP6.0 1220) (click here)

Biotikon - What makes us Special:

  • First company in the world to consistently use no additives in the capsule filling
  • Own production for over 20 years
  • 40 years of experience in plant science
  • Ultra-clean premium extracts of the highest quality
  • Capsule shells free of PEG (polyethylene glycol) and carrageenan
  • Made in Germany
  • Highest standard in food safety: HACCP & ISO 9001
  • Sustainable, plastic-free shipping
  • Fast delivery
  • Own plantation project
  • Support of social projects
  • Owner-managed company based in Germany
  • Highly professional analysis laboratory
  • Team of doctors and alternative practitioners
  • Personal advice hotline
Natur + Reinheit

 Made in Germany.

OPCPlus by Dr. Michalzik is subject to strict examinations of German supervisory authorities. It is manufactured by use of gentle production technologies without heat or additives in the capsule filling and without the use of processing agents which are not required to be mentioned on the packaging.
No industrially produced silicic acid (silicon dioxide) flow aid.
Biotikon does not use silicon dioxide or silicic acid (SiO2, known as E551) as a flow aid. The foundation for product testing "Stiftung Warentest" states that those may contain nanoparticles. Silicic acid or silicon dioxide in dietary supplements has been discouraged. Bio Suisse has terminated approval of silica or silicon dioxide. Silica from horsetail is not to be confused with this industrially produced silica.
No Aluminum Contained
A large number of nutritional supplement providers use aluminum as a sealant for cans. During the sealing process an aluminum foil is strongly heated by a high frequency electromagnetic field. We deliberately do not use this method!
Without talcum!
The release agent and lubricant talcum which is used for manufacturing of tablets or capsules can contain asbestos fibers. Biotikon completely dispenses with the use of release agents and lubricants in their capsule production.
Fresh Products!
From the date of sale all of our products have a long lasting shelf life. This is possible because we process in house.
Food Safety HACCP
Biotikon products are manufactured in accordance with legal requirements and in compliance with the HACCP concept in order to ensure food safety.
Please note: With each purchase, you are also automatically supporting chosen social projects. Further information can be found in our blog under Social Engagement .

Free of sugar
Free of lactose
Free of Gluten
Free of gelatin
Not irradiated
Free of magenseium stearate

OPC is contained in the following products:

OPC Wirkung
Gehirn und geistige Leistung Brain & Mental Performance
Augen Rezeptur Eye Formula
Herzforte 1 I Heart Forte I
Blutdruck Regulat Blood Pressure Regulator
Gelenk-Rezeptur II Joint Formula II
Arterien Blutgefäß Support Arterial & Blood Vessel Support
Sport Concept cell protect Sport - cell protect
Mitochondrium forte/Pro Mitochondrium forte / forte PRO

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Ingredients per Daily Recommendation, 1 casule:
extract of Vitis vinifera
300 mg
   total polyphenols
285 mg
160 mg
Camu Camu extract
50 mg
300 mg OPC grape seed extract containig 160 mg pure, genuine OPC measured directly in the grape seed extract. (According to RP-HPLC method, test specification PV.03.P194_02). OPC are proanthocyanidins. Monomeric proanthocyanidins are not added into the OPCs. Test specifications are available at www.opc-grapeseedextract.de
50 mg

Our OPCplus contains 50 mg of pure camu camu extract per capsule.

Ingredients: Vitis vinifera extract, camu camu extract from Myrciaria dubia, capsule material made of pure vegetable cellulose (Hydroxy-propyl-methyl-cellulose

Purest Quality from Biotikon®

Pure substances without additives or fillers in the capsule filling
Gluten-free, lactose-free and gelatine-free
Information about residue control: please contact us
Packaging made of HDPE, no plasticisers
Without animal testing
We deliver fresh products
The following diagram is intended to illustrate the different ingredients of grape seed extract.

OPC concentration prozess

OPC-Concentration Process

1. Plant polyphenols are so-called secondary plant compounds.

2. OPC stands for oligomeric procyanidins. They consist of catechins, which are connected by condensation. This produces substances with a new identity which include a larger range of efficiency than single (= monomeric) catechins. They are called pro- (proantho) cyanidines which at splitting of the compound do not disintegrate into catechins but cyanidins. Green tea for example contains only monomeric (single) catechins, which cannot have the same effect as OPC. A peeled banana will turn brown, iron will rust. The reason is the oxidation of these substances or tissues through radical oxygen molecules (free radicals).
Daily Dosage:
1 -2 OPC plus-capsules.

Package Contents: 72 OPC 160 plus-capsules. Each capsule contains 300 mg grape seed extract and 50 mg camu camu extract.

Storage: Keep cool & dry, protect from light exposure.

Important Note: The recommended daily dose should not be exceeded. Nutritional supplements are not intended to be a substitute for a varied and balanced diet or a healthy lifestyle. Children, pregnant women, and nursing mothers should consult with a doctor before using this product. Keep out of reach of children.
Additional Information:

When buying OPC products the following criteria should be taken into consideration:
  • Documented OPC content with RP-HPLC analysis certificate

  • Product should be processed in Germany / German suppliers: Verifiability and security ensured by controllability

  • No fillers and additives

  • OPC originates from grape seeds. Much knowledge about the product is received from red wine.
OPC-products from Biotikon® compared

Article details

29,90 €

300 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik, M.D. with at least 160 mg of pure OPC*

72 Capsules

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32,90 €

300 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik and Camu Camu extract with at least 160 mg of pure OPC*

72 Capsules

OPC Premium
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39,90 €

450 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik, M.D. with at least 240 mg of pure OPC*

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OPC Premium Plus
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42,90 €

450 mg of OPC Premium Grape Seed Extract per capsule by Dr. Michalzik, M.D. with Camu Camu extract and at least 240 mg of pure OPC*

72 Capsules

OPC Premium Piperine PRO
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47,90 €

450 mg of OPC premium grape seed extract per capsule by Dr. Michalzik, containing Piperine and phosphatidylcholine with at least 240 mg of pure OPC*

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OPC from Organic Grapes
Article details

59,90 €

- currently not available

60 Capsules

Your Biotikon® Advantages:

  • Made in Germany
  • Premium-quality extract
  • Capsule contains
    no additives*
  • free shipping on orders over 70 Euro
  • with also on packing stations,
  • GB 3 - 5 days
  • DE 1 - 3 days
  • AT, CH, EU 3 - 5 days
Order by phone
+49 (0)6201-878380
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and Sat.:
9 a.m. till 4 p.m.
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